Pseudomonas aeruginosa PAO1, PA4034 (aqpZ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4034
Name
aqpZ
Synonym: bniP
Replicon chromosome
Genomic location 4514695 - 4515384 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252723.1
GI 15599229
Affymetrix PA4034_aqpZ_at
Entrez 879049
GenBank AAG07421.1
INSDC AAG07421.1
NCBI Locus Tag PA4034
protein_id(GenBank) gb|AAG07421.1|AE004820_6|gnl|PseudoCAP|PA4034
TIGR NTL03PA04034
UniParc UPI00000C5BD1
UniProtKB Acc Q9HWZ3
UniProtKB ID AQPZ_PSEAE
UniRef100 UniRef100_Q9HWZ3
UniRef50 UniRef50_Q9HWZ3
UniRef90 UniRef90_Q9HWZ3

Product

Feature Type CDS
Coding Frame 1
Product Name
aquaporin Z
Product Name Confidence: Class 2
Synonyms bacterial nodulin-like intrinsic protein
water channel protein
Evidence for Translation
Charge (pH 7) 0.67
Kyte-Doolittle Hydrophobicity Value 0.875
Molecular Weight (kDa) 23.3
Isoelectric Point (pI) 7.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 327 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001650 (438 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4034
Search term: aqpZ
Search term: aquaporin Z

Human Homologs

Ensembl 110, assembly GRCh38.p14
aquaporin 5 [Source:HGNC Symbol;Acc:HGNC:638]
E-value: 2.3e-28
Percent Identity: 37.9

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Molecular cloning and characterization of AqpZ, a water channel from Escherichia coli.
Calamita G, Bishai WR, Preston GM, Guggino WB, Agre P
J Biol Chem 1995 Dec 8;270(49):29063-6
PubMed ID: 7493926
Isolation of a gene encoding nodulin-like intrinsic protein of Escherichia coli.
Fushimi K, Bai L, Marumo F, Sasaki S
Biochem Mol Biol Int 1997 Apr;41(5):995-1003
PubMed ID: 9137831