Pseudomonas aeruginosa PAO1, PA4125 (hpcD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4125
Name
hpcD
Replicon chromosome
Genomic location 4613539 - 4613931 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252814.1
GI 15599320
Affymetrix PA4125_hpcD_at
DNASU PaCD00007798
Entrez 878649
GenBank AAG07512.1
INSDC AAG07512.1
NCBI Locus Tag PA4125
protein_id(GenBank) gb|AAG07512.1|AE004829_2|gnl|PseudoCAP|PA4125
TIGR NTL03PA04125
UniParc UPI00000C5C22
UniProtKB Acc Q9HWQ6
UniProtKB ID Q9HWQ6_PSEAE
UniRef100 UniRef100_W0YYE5
UniRef50 UniRef50_Q05354
UniRef90 UniRef90_Q02ST9

Product

Feature Type CDS
Coding Frame 1
Product Name
5-carboxymethyl-2-hydroxymuconate isomerase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.59
Kyte-Doolittle Hydrophobicity Value -0.215
Molecular Weight (kDa) 14.7
Isoelectric Point (pI) 5.55

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 61 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001574 (357 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4125
Search term: hpcD

Human Homologs

References

Purification, some properties and nucleotide sequence of 5-carboxymethyl-2-hydroxymuconate isomerase of Escherichia coli C.
Roper DI, Cooper RA
FEBS Lett 1990 Jun 18;266(1-2):63-6
PubMed ID: 2194841
Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.
Subramanya HS, Roper DI, Dauter Z, Dodson EJ, Davies GJ, Wilson KS, Wigley DB
Biochemistry 1996 Jan 23;35(3):792-802
PubMed ID: 8547259