Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA4136
|
Name |
Synonym: sur Synonym: bcr |
Replicon | chromosome |
Genomic location | 4625089 - 4626297 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_252825.1 |
GI | 15599331 |
Affymetrix | PA4136_at |
Entrez | 880090 |
GenBank | AAG07523.1 |
INSDC | AAG07523.1 |
NCBI Locus Tag | PA4136 |
protein_id(GenBank) | gb|AAG07523.1|AE004830_4|gnl|PseudoCAP|PA4136 |
TIGR | NTL03PA04136 |
UniParc | UPI00000C5C2D |
UniProtKB Acc | Q9HWP5 |
UniProtKB ID | Q9HWP5_PSEAE |
UniRef100 | UniRef100_W0YYG1 |
UniRef50 | UniRef50_W9UZ83 |
UniRef90 | UniRef90_A0A077JIN6 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
probable major facilitator superfamily (MFS) transporter
|
Synonyms |
probable MFS transporter |
Evidence for Translation | |
Charge (pH 7) | 13.88 |
Kyte-Doolittle Hydrophobicity Value | 0.962 |
Molecular Weight (kDa) | 41.8 |
Isoelectric Point (pI) | 9.67 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
bcr-1 | Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. [PMID:25085655, PMID:26093374] | ARO:3003801 | protein homolog model | Perfect | 758.1 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 569 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001563 (351 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA4136
|
Gene amplification contributes to sulfonamide resistance in Escherichia coli.
Nichols BP, Guay GG
Antimicrob Agents Chemother 1989 Dec;33(12):2042-8
PubMed ID: 2694948
|
Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli.
Vedantam G, Guay GG, Austria NE, Doktor SZ, Nichols BP
Antimicrob Agents Chemother 1998 Jan;42(1):88-93
PubMed ID: 9449266
|