Pseudomonas aeruginosa PAO1, PA4136

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4136
Name
Synonym: sur
Synonym: bcr
Replicon chromosome
Genomic location 4625089 - 4626297 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252825.1
GI 15599331
Affymetrix PA4136_at
Entrez 880090
GenBank AAG07523.1
INSDC AAG07523.1
NCBI Locus Tag PA4136
protein_id(GenBank) gb|AAG07523.1|AE004830_4|gnl|PseudoCAP|PA4136
TIGR NTL03PA04136
UniParc UPI00000C5C2D
UniProtKB Acc Q9HWP5
UniProtKB ID Q9HWP5_PSEAE
UniRef100 UniRef100_W0YYG1
UniRef50 UniRef50_W9UZ83
UniRef90 UniRef90_A0A077JIN6

Product

Feature Type CDS
Coding Frame 1
Product Name
probable major facilitator superfamily (MFS) transporter
Product Name Confidence: Class 3
Synonyms probable MFS transporter
Evidence for Translation
Charge (pH 7) 13.88
Kyte-Doolittle Hydrophobicity Value 0.962
Molecular Weight (kDa) 41.8
Isoelectric Point (pI) 9.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
bcr-1 Transmembrane protein which expels bicyclomycin from the cell, leading to bicyclomycin resistance. Identified in Pseudomonas aeruginosa strains responsible for outbreaks in Brazil, often appearing with blaSPM-1, another bicyclomycin resistance gene. [PMID:25085655, PMID:26093374] ARO:3003801 protein homolog model Perfect 758.1 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 569 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001563 (351 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4136

Human Homologs

References

Gene amplification contributes to sulfonamide resistance in Escherichia coli.
Nichols BP, Guay GG
Antimicrob Agents Chemother 1989 Dec;33(12):2042-8
PubMed ID: 2694948
Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli.
Vedantam G, Guay GG, Austria NE, Doktor SZ, Nichols BP
Antimicrob Agents Chemother 1998 Jan;42(1):88-93
PubMed ID: 9449266