Pseudomonas aeruginosa PAO1, PA4143

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4143
Name
Synonym: cvaB
Synonym: cyaB
Replicon chromosome
Genomic location 4634139 - 4636298 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252832.1
GI 15599338
Affymetrix PA4143_at
Entrez 880113
GenBank AAG07530.1
INSDC AAG07530.1
NCBI Locus Tag PA4143
protein_id(GenBank) gb|AAG07530.1|AE004831_2|gnl|PseudoCAP|PA4143
TIGR NTL03PA04143
UniParc UPI00000C5C34
UniProtKB Acc Q9HWN8
UniProtKB ID Q9HWN8_PSEAE
UniRef100 UniRef100_W0YXX9
UniRef50 UniRef50_A0A085HJS3
UniRef90 UniRef90_A6UZU7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable toxin transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 6.17
Kyte-Doolittle Hydrophobicity Value 0.202
Molecular Weight (kDa) 79.6
Isoelectric Point (pI) 8.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 669 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001556 (830 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4143

Human Homologs

Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50]
E-value: 4.1e-47
Percent Identity: 26.0
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50]
E-value: 4.1e-47
Percent Identity: 26.0
Ensembl 110, assembly GRCh38.p14
ATP binding cassette subfamily B member 9 [Source:HGNC Symbol;Acc:HGNC:50]
E-value: 4.1e-47
Percent Identity: 26.0

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Genetic analysis of an MDR-like export system: the secretion of colicin V.
Gilson L, Mahanty HK, Kolter R
EMBO J 1990 Dec;9(12):3875-84
PubMed ID: 2249654