Pseudomonas aeruginosa PAO1, PA4159 (fepB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4159
Name
fepB
Replicon chromosome
Genomic location 4654432 - 4655337 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252848.1
GI 15599354
Affymetrix PA4159_fepB_at
DNASU PaCD00007808
Entrez 880322
GenBank AAG07546.1
INSDC AAG07546.1
NCBI Locus Tag PA4159
protein_id(GenBank) gb|AAG07546.1|AE004832_6|gnl|PseudoCAP|PA4159
TIGR NTL03PA04159
UniParc UPI00000C5C44
UniProtKB Acc Q9HWM2
UniProtKB ID Q9HWM2_PSEAE
UniRef100 UniRef100_Q9HWM2
UniRef50 UniRef50_Q9HWM2
UniRef90 UniRef90_Q9HWM2

Product

Feature Type CDS
Coding Frame 1
Product Name
ferrienterobactin-binding periplasmic protein precursor FepB
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.28
Kyte-Doolittle Hydrophobicity Value 0.079
Molecular Weight (kDa) 32.1
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 56 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001542 (299 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4159
Search term: fepB

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB.
Elkins MF, Earhart CF
J Bacteriol 1989 Oct;171(10):5443-51
PubMed ID: 2529253
Escherichia coli periplasmic protein FepB binds ferrienterobactin.
Stephens DL, Choe MD, Earhart CF
Microbiology (Reading) 1995 Jul;141 ( Pt 7):1647-54
PubMed ID: 7551033