Pseudomonas aeruginosa PAO1, PA4168 (fpvB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4168
Name
fpvB
Replicon chromosome
Genomic location 4663854 - 4666262 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentIron limitation induces transcription of fpvA and fpvB.

Cross-References

RefSeq NP_252857.1
GI 15599363
Affymetrix PA4168_at
Entrez 880246
GenBank AAG07555.1
INSDC AAG07555.1
NCBI Locus Tag PA4168
protein_id(GenBank) gb|AAG07555.1|AE004833_6|gnl|PseudoCAP|PA4168
TIGR NTL03PA04168
UniParc UPI00000C5C4D
UniProtKB Acc Q9HWL3
UniProtKB ID Q9HWL3_PSEAE
UniRef100 UniRef100_Q9HWL3
UniRef50 UniRef50_Q9HWL3
UniRef90 UniRef90_Q9HWL3

Product

Feature Type CDS
Coding Frame 1
Product Name
second ferric pyoverdine receptor FpvB
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -9.22
Kyte-Doolittle Hydrophobicity Value -0.455
Molecular Weight (kDa) 87.4
Isoelectric Point (pI) 5.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 267 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001486 (1037 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4168
Search term: fpvB

Human Homologs

References

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa.
Ghysels B, Dieu BTM, Beatson SA, Pirnay JP, Ochsner UA, Vasil ML, Cornelis P
Microbiology (Reading) 2004 Jun;150(Pt 6):1671-1680
PubMed ID: 15184553
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Sequence of the fhuE outer-membrane receptor gene of Escherichia coli K12 and properties of mutants.
Sauer M, Hantke K, Braun V
Mol Microbiol 1990 Mar;4(3):427-37
PubMed ID: 2162465
The ferric-pseudobactin receptor PupA of Pseudomonas putida WCS358: homology to TonB-dependent Escherichia coli receptors and specificity of the protein.
Bitter W, Marugg JD, de Weger LA, Tommassen J, Weisbeek PJ
Mol Microbiol 1991 Mar;5(3):647-55
PubMed ID: 1646376
Identification and characterization of the pupB gene encoding an inducible ferric-pseudobactin receptor of Pseudomonas putida WCS358.
Koster M, van de Vossenberg J, Leong J, Weisbeek PJ
Mol Microbiol 1993 May;8(3):591-601
PubMed ID: 8392140
Cloning and nucleotide sequence analysis of the ferripyoverdine receptor gene fpvA of Pseudomonas aeruginosa.
Poole K, Neshat S, Krebes K, Heinrichs DE
J Bacteriol 1993 Aug;175(15):4597-604
PubMed ID: 8335619
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994