Pseudomonas aeruginosa PAO1, PA0035 (trpA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0035
|
| Name |
trpA
|
| Replicon | chromosome |
| Genomic location | 37087 - 37893 (- strand) |
| Transposon Mutants | 3 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_248725.1 |
| GI | 15595233 |
| Affymetrix | PA0035_trpA_at |
| DNASU | PaCD00006017 |
| Entrez | 879479 |
| GenBank | AAG03425.1 |
| INSDC | AAG03425.1 |
| NCBI Locus Tag | PA0035 |
| protein_id(GenBank) | gb|AAG03425.1|AE004443_3|gnl|PseudoCAP|PA0035 |
| TIGR | NTL03PA00036 |
| UniParc | UPI00001374E5 |
| UniProtKB Acc | P07344 |
| UniProtKB ID | TRPA_PSEAE |
| UniRef100 | UniRef100_P07344 |
| UniRef50 | UniRef50_P07344 |
| UniRef90 | UniRef90_P07344 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
tryptophan synthase alpha chain
|
| Synonyms | |
| Evidence for Translation |
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -8.37 |
| Kyte-Doolittle Hydrophobicity Value | 0.061 |
| Molecular Weight (kDa) | 28.5 |
| Isoelectric Point (pI) | 5.00 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 581 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000035 (554 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0035
Search term: trpA
Search term: tryptophan synthase alpha chain
|
Human Homologs
References
|
Nucleotide sequence of the genes for tryptophan synthase in Pseudomonas aeruginosa.
Hadero A, Crawford IP
Mol Biol Evol 1986 May;3(3):191-204
PubMed ID: 3127651
|
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|