Pseudomonas aeruginosa PAO1, PA0067 (prlC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0067
Name
prlC
Synonym: opdA
Replicon chromosome
Genomic location 78710 - 80755 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248757.1
GI 15595265
Affymetrix PA0067_prlC_at
Entrez 878482
GenBank AAG03457.1
INSDC AAG03457.1
NCBI Locus Tag PA0067
protein_id(GenBank) gb|AAG03457.1|AE004446_5|gnl|PseudoCAP|PA0067
TIGR NTL03PA00068
UniParc UPI00000C4F14
UniProtKB Acc Q9I765
UniProtKB ID Q9I765_PSEAE
UniRef100 UniRef100_Q9I765
UniRef50 UniRef50_G8PY41
UniRef90 UniRef90_Q9I765

Product

Feature Type CDS
Coding Frame 1
Product Name
oligopeptidase A
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -24.80
Kyte-Doolittle Hydrophobicity Value -0.253
Molecular Weight (kDa) 76.0
Isoelectric Point (pI) 4.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 335 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000066 (550 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0067
Search term: prlC
Search term: oligopeptidase A

Human Homologs

Ensembl 107, assembly GRCh38.p13
neurolysin [Source:HGNC Symbol;Acc:HGNC:16058]
E-value: 9.6e-75
Percent Identity: 28.7

References

Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene.
Conlin CA, Trun NJ, Silhavy TJ, Miller CG
J Bacteriol 1992 Sep;174(18):5881-7
PubMed ID: 1325967
Escherichia coli prlC gene encodes a trypsin-like proteinase regulating the cell cycle.
Jiang X, Zhang M, Ding Y, Yao J, Chen H, Zhu D, Muramatu M
J. Biochem. 1998 Nov;124(5):980-5
PubMed ID: 9792922
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994