Pseudomonas aeruginosa PAO1, PA0122 (rahU)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0122
|
| Name |
rahU
|
| Replicon | chromosome |
| Genomic location | 141917 - 142327 (+ strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
Cross-References
| RefSeq | NP_248812.1 |
| GI | 15595320 |
| Affymetrix | PA0122_at |
| DNASU | PaCD00006054 |
| Entrez | 880611 |
| GenBank | AAG03512.1 |
| INSDC | AAG03512.1 |
| NCBI Locus Tag | PA0122 |
| protein_id(GenBank) | gb|AAG03512.1|AE004450_7|gnl|PseudoCAP|PA0122 |
| TIGR | NTL03PA00123 |
| UniParc | UPI00000C4F4A |
| UniProtKB Acc | Q9I710 |
| UniProtKB ID | Q9I710_PSEAE |
| UniRef100 | UniRef100_W0YKT2 |
| UniRef50 | UniRef50_A6UXQ8 |
| UniRef90 | UniRef90_W0YKT2 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
rahU
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -4.08 |
| Kyte-Doolittle Hydrophobicity Value | -0.386 |
| Molecular Weight (kDa) | 14.6 |
| Isoelectric Point (pI) | 4.41 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6ZC1 | TOXIN | 06/09/20 | Crystal structure of RahU protein from Pseudomonas aeruginosa | Pseudomonas aeruginosa PAO1 | 1.27 | X-RAY DIFFRACTION | 100.0 |
| 6ZC2 | TOXIN | 06/09/20 | Crystal structure of RahU protein in complex with TRIS molecule | Pseudomonas aeruginosa PAO1 | 1.13 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000120 (304 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0122
Search term: rahU
Search term: rahU
|
Human Homologs
References
|
Cloning and nucleotide sequence of cDNA encoding Asp-hemolysin from Aspergillus fumigatus.
Ebina K, Sakagami H, Yokota K, Kondo H
Biochim. Biophys. Acta 1994 Sep;1219(1):148-50
PubMed ID: 8086452
|
|
Host derived inflammatory phospholipids regulate rahU (PA0122) gene, protein, and biofilm formation in Pseudomonas aeruginosa.
Rao J, DiGiandomenico A, Artamonov M, Leitinger N, Amin AR, Goldberg JB
Cell. Immunol. 2011 ;270(2):95-102
PubMed ID: 21679933
|
|
RahU: an inducible and functionally pleiotropic protein in Pseudomonas aeruginosa modulates innate immunity and inflammation in host cells.
Rao J, Elliott MR, Leitinger N, Jensen RV, Goldberg JB, Amin AR
Cell. Immunol. 2011 ;270(2):103-13
PubMed ID: 21704311
|
|
A novel oxidized low-density lipoprotein-binding protein from Pseudomonas aeruginosa.
Rao J, DiGiandomenico A, Unger J, Bao Y, Polanowska-Grabowska RK, Goldberg JB
Microbiology (Reading, Engl.) 2008 Feb;154(Pt 2):654-65
PubMed ID: 18227268
|