Pseudomonas aeruginosa PAO1, PA0124

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0124
Name
Replicon chromosome
Genomic location 143567 - 143848 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentParDE toxin_antitoxin system

Cross-References

RefSeq NP_248814.1
GI 15595322
Affymetrix PA0124_at
DNASU PaCD00006056
Entrez 879205
GenBank AAG03514.1
INSDC AAG03514.1
NCBI Locus Tag PA0124
protein_id(GenBank) gb|AAG03514.1|AE004450_9|gnl|PseudoCAP|PA0124
TIGR NTL03PA00125
UniParc UPI00000C4F4C
UniProtKB Acc Q9I708
UniProtKB ID Q9I708_PSEAE
UniRef100 UniRef100_W0YM54
UniRef50 UniRef50_A6UXR1
UniRef90 UniRef90_A6UXR1

Product

Feature Type CDS
Coding Frame 1
Product Name
ParE toxin
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.22
Kyte-Doolittle Hydrophobicity Value -0.217
Molecular Weight (kDa) 10.5
Isoelectric Point (pI) 10.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6XRW TOXIN/ANTITOXIN 07/13/20 Chromosomal ParDE TA system from P. aeruginosa Pseudomonas aeruginosa 1.77 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 14 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000122 (310 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0124
Search term: ParE toxin

Human Homologs

References

The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.
Muthuramalingam M, White JC, Murphy T, Ames JR, Bourne CR
Mol Microbiol 2019 Feb;111(2):441-454
PubMed ID: 30427086