Pseudomonas aeruginosa PAO1, PA0125
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0125
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 143845 - 144072 (- strand) |
| Comment | ParDE toxin_antitoxin system |
Cross-References
| RefSeq | NP_248815.1 |
| GI | 15595323 |
| Affymetrix | PA0125_at |
| DNASU | PaCD00006057 |
| Entrez | 880838 |
| GenBank | AAG03515.1 |
| INSDC | AAG03515.1 |
| NCBI Locus Tag | PA0125 |
| protein_id(GenBank) | gb|AAG03515.1|AE004450_10|gnl|PseudoCAP|PA0125 |
| TIGR | NTL03PA00126 |
| UniParc | UPI00000C4F4D |
| UniProtKB Acc | Q9I707 |
| UniProtKB ID | Q9I707_PSEAE |
| UniRef100 | UniRef100_Q9I707 |
| UniRef50 | UniRef50_Q9I707 |
| UniRef90 | UniRef90_Q9I707 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
ParD antitoxin
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -2.29 |
| Kyte-Doolittle Hydrophobicity Value | -0.397 |
| Molecular Weight (kDa) | 8.6 |
| Isoelectric Point (pI) | 5.58 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 6XRW | TOXIN/ANTITOXIN | 07/13/20 | Chromosomal ParDE TA system from P. aeruginosa | Pseudomonas aeruginosa | 1.77 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 23 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000123 (334 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0125
Search term: ParD antitoxin
|
Human Homologs
References
|
The toxin from a ParDE toxin-antitoxin system found in Pseudomonas aeruginosa offers protection to cells challenged with anti-gyrase antibiotics.
Muthuramalingam M, White JC, Murphy T, Ames JR, Bourne CR
Mol Microbiol 2019 Feb;111(2):441-454
PubMed ID: 30427086
|