Pseudomonas aeruginosa PAO1, PA0130 (bauC)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0130
|
| Name |
bauC
|
| Replicon | chromosome |
| Genomic location | 147561 - 149054 (- strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_248820.1 |
| GI | 15595328 |
| Affymetrix | PA0130_at |
| Entrez | 880875 |
| GenBank | AAG03520.1 |
| INSDC | AAG03520.1 |
| NCBI Locus Tag | PA0130 |
| protein_id(GenBank) | gb|AAG03520.1|AE004451_1|gnl|PseudoCAP|PA0130 |
| TIGR | NTL03PA00131 |
| UniParc | UPI00000C4F52 |
| UniProtKB Acc | Q9I702 |
| UniProtKB ID | BAUC_PSEAE |
| UniRef100 | UniRef100_Q9I702 |
| UniRef50 | UniRef50_Q9I702 |
| UniRef90 | UniRef90_Q9I702 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
3-Oxopropanoate dehydrogenase
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -7.37 |
| Kyte-Doolittle Hydrophobicity Value | -0.014 |
| Molecular Weight (kDa) | 53.3 |
| Isoelectric Point (pI) | 5.95 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5TJR | OXIDOREDUCTASE | 10/05/16 | X-ray Crystal structure of a methylmalonate semialdehyde dehydrogenase from Pseudomonas sp. AAC | Pseudomonas sp. AAC | 2.95 | X-RAY DIFFRACTION | 91.5 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 599 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000128 (548 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0130
Search term: bauC
Search term: 3-Oxopropanoate dehydrogenase
|
Human Homologs
|
Ensembl
107, assembly
GRCh38.p13
|
aldehyde dehydrogenase 6 family member A1 [Source:HGNC Symbol;Acc:HGNC:7179]
E-value:
2.3e-126
Percent Identity:
45.6
|
References
|
Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750
|