Pseudomonas aeruginosa PAO1, PA0132 (bauA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0132
Name
bauA
Synonym: oapT
Replicon chromosome
Genomic location 149425 - 150771 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_248822.1
GI 15595330
Affymetrix PA0132_at
Entrez 879350
GenBank AAG03522.1
INSDC AAG03522.1
NCBI Locus Tag PA0132
protein_id(GenBank) gb|AAG03522.1|AE004451_3|gnl|PseudoCAP|PA0132
TIGR NTL03PA00133
UniParc UPI00000C4F54
UniProtKB Acc Q9I700
UniProtKB ID BAUA_PSEAE
UniRef100 UniRef100_Q9I700
UniRef50 UniRef50_Q9I700
UniRef90 UniRef90_Q9I700

Product

Feature Type CDS
Coding Frame 1
Product Name
Beta-alanine:pyruvate transaminase
Product Name Confidence: Class 1
Synonyms omega-amino acid--pyruvate transaminase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.78
Kyte-Doolittle Hydrophobicity Value -0.098
Molecular Weight (kDa) 48.4
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4B98 TRANSFERASE 09/03/12 The structure of the omega aminotransferase from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.65 X-RAY DIFFRACTION 100.0
4BQ0 TRANSFERASE 05/29/13 Pseudomonas aeruginosa beta-alanine:pyruvate aminotransferase holoenzyme without divalent cations on dimer-dimer interface PSEUDOMONAS AERUGINOSA 1.77 X-RAY DIFFRACTION 100.0
4B9B TRANSFERASE 09/03/12 The structure of the omega aminotransferase from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 1.64 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000130 (871 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0132
Search term: bauA

Human Homologs

Ensembl 107, assembly GRCh38.p13
ornithine aminotransferase [Source:HGNC Symbol;Acc:HGNC:8091]
E-value: 6.4e-35
Percent Identity: 27.0

References

The primary structure of omega-amino acid:pyruvate aminotransferase.
Yonaha K, Nishie M, Aibara S
J Biol Chem 1992 Jun 25;267(18):12506-10
PubMed ID: 1618757
Functional characterization of seven γ-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and β-Alanine utilization in Pseudomonas aeruginosa PAO1.
Yao X, He W, Lu CD
J. Bacteriol. 2011 Aug;193(15):3923-30
PubMed ID: 21622750