Pseudomonas aeruginosa PAO1, PA0139 (ahpC)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Replicon chromosome
Genomic location 158199 - 158762 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_248829.1
GI 15595337
Affymetrix PA0139_ahpC_at
DNASU PaCD00006061
Entrez 879431
GenBank AAG03529.1
INSDC AAG03529.1
NCBI Locus Tag PA0139
protein_id(GenBank) gb|AAG03529.1|AE004452_1|gnl|PseudoCAP|PA0139
UniParc UPI00000C4F5B
UniProtKB Acc Q9I6Z3
UniRef100 UniRef100_Q02UU0
UniRef50 UniRef50_Q02UU0
UniRef90 UniRef90_Q02UU0


Feature Type CDS
Coding Frame 1
Product Name
alkyl hydroperoxide reductase subunit C
Product Name Confidence: Class 2
Evidence for Translation
Verified using two-dimensional gel electrophoresis, MALDI-TOF MS and peptide mass mapping(pI:5.9, molecular weight:20.5, PMID:21674802)
Detected using LC-MS/MS (20.54 kDa, PMID:21751344)
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.14
Kyte-Doolittle Hydrophobicity Value -0.182
Molecular Weight (kDa) 20.5
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 590 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000137 (535 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0139
Search term: ahpC

Human Homologs

Ensembl 110, assembly GRCh38.p14
peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354]
E-value: 8.7e-34
Percent Identity: 42.5


Isolation and analysis of the Xanthomonas alkyl hydroperoxide reductase gene and the peroxide sensor regulator genes ahpC and ahpF-oxyR-orfX.
Loprasert S, Atichartpongkun S, Whangsuk W, Mongkolsuk S
J Bacteriol 1997 Jun;179(12):3944-9
PubMed ID: 9190810
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.
Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ
Proteomics 2011 Aug;11(15):3056-69
PubMed ID: 21674802
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344