Pseudomonas aeruginosa PAO1, PA0139 (ahpC)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0139
|
| Name |
ahpC
|
| Replicon | chromosome |
| Genomic location | 158199 - 158762 (+ strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_248829.1 |
| GI | 15595337 |
| Affymetrix | PA0139_ahpC_at |
| DNASU | PaCD00006061 |
| Entrez | 879431 |
| GenBank | AAG03529.1 |
| INSDC | AAG03529.1 |
| NCBI Locus Tag | PA0139 |
| protein_id(GenBank) | gb|AAG03529.1|AE004452_1|gnl|PseudoCAP|PA0139 |
| TIGR | NTL03PA00140 |
| UniParc | UPI00000C4F5B |
| UniProtKB Acc | Q9I6Z3 |
| UniProtKB ID | Q9I6Z3_PSEAE |
| UniRef100 | UniRef100_Q02UU0 |
| UniRef50 | UniRef50_Q02UU0 |
| UniRef90 | UniRef90_Q02UU0 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
alkyl hydroperoxide reductase subunit C
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Verified using two-dimensional gel electrophoresis, MALDI-TOF MS and peptide mass mapping(pI:5.9, molecular weight:20.5, PMID:21674802)
Detected using LC-MS/MS (20.54 kDa, PMID:21751344)
Detected by MALDI-TOF/TOF (PMID:19333994).
|
| Charge (pH 7) | -3.14 |
| Kyte-Doolittle Hydrophobicity Value | -0.182 |
| Molecular Weight (kDa) | 20.5 |
| Isoelectric Point (pI) | 6.30 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 590 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000137 (552 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0139
Search term: ahpC
Search term: alkyl hydroperoxide reductase subunit C
|
Human Homologs
|
Ensembl
107, assembly
GRCh38.p13
|
peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354]
E-value:
8.5e-34
Percent Identity:
42.5
|
References
|
Isolation and analysis of the Xanthomonas alkyl hydroperoxide reductase gene and the peroxide sensor regulator genes ahpC and ahpF-oxyR-orfX.
Loprasert S, Atichartpongkun S, Whangsuk W, Mongkolsuk S
J. Bacteriol. 1997 Jun;179(12):3944-9
PubMed ID: 9190810
|
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|
|
Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.
Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ
Proteomics 2011 Aug;11(15):3056-69
PubMed ID: 21674802
|
|
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
|