Pseudomonas aeruginosa PAO1, PA0208 (mdcA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0208
|
| Name |
mdcA
|
| Replicon | chromosome |
| Genomic location | 237232 - 238896 (+ strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_248899.1 |
| GI | 15595405 |
| Affymetrix | PA0208_mdcA_at |
| Entrez | 879322 |
| GenBank | AAG03597.1 |
| INSDC | AAG03597.1 |
| NCBI Locus Tag | PA0208 |
| protein_id(GenBank) | gb|AAG03597.1|AE004459_1|gnl|PseudoCAP|PA0208 |
| TIGR | NTL03PA00209 |
| UniParc | UPI00000C4F98 |
| UniProtKB Acc | Q9I6T0 |
| UniProtKB ID | Q9I6T0_PSEAE |
| UniRef100 | UniRef100_Q9I6T0 |
| UniRef50 | UniRef50_O06924 |
| UniRef90 | UniRef90_Q9I6T0 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
malonate decarboxylase alpha subunit
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -5.21 |
| Kyte-Doolittle Hydrophobicity Value | -0.182 |
| Molecular Weight (kDa) | 61.4 |
| Isoelectric Point (pI) | 6.42 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 5VJ1 | TRANSFERASE | 04/18/17 | Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with coenzyme A | Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) | 2.995 | X-RAY DIFFRACTION | 100.0 |
| 5VIT | TRANSFERASE | 04/17/17 | Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with malonate | Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) | 2.203 | X-RAY DIFFRACTION | 100.0 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 59 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000207 (490 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0208
Search term: mdcA
Search term: malonate decarboxylase alpha subunit
|
Human Homologs
References
|
Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli.
Hoenke S, Schmid M, Dimroth P
Eur. J. Biochem. 1997 Jun;246(2):530-8
PubMed ID: 9208947
|