Pseudomonas aeruginosa PAO1, PA0464 (creC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0464
Name
creC
Synonym: phoM
Replicon chromosome
Genomic location 523943 - 525367 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249155.1
GI 15595661
Affymetrix PA0464_creC_at
Entrez 881807
GenBank AAG03853.1
INSDC AAG03853.1
NCBI Locus Tag PA0464
protein_id(GenBank) gb|AAG03853.1|AE004484_5|gnl|PseudoCAP|PA0464
TIGR NTL03PA00465
UniParc UPI00000C506E
UniProtKB Acc Q9I654
UniProtKB ID Q9I654_PSEAE
UniRef100 UniRef100_Q9I654
UniRef50 UniRef50_Q4K4R3
UniRef90 UniRef90_Q9I654

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor CreC
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.04
Kyte-Doolittle Hydrophobicity Value -0.203
Molecular Weight (kDa) 52.3
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 618 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000456 (446 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0464
Search term: creC

Human Homologs

References

Cross talk to the phosphate regulon of Escherichia coli by PhoM protein: PhoM is a histidine protein kinase and catalyzes phosphorylation of PhoB and PhoM-open reading frame 2.
Amemura M, Makino K, Shinagawa H, Nakata A
J Bacteriol 1990 Nov;172(11):6300-7
PubMed ID: 2228961