Pseudomonas aeruginosa PAO1, PA0650 (trpD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0650
Name
trpD
Replicon chromosome
Genomic location 704084 - 705133 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249341.1
GI 15595847
Affymetrix PA0650_trpD_at
Entrez 880665
GenBank AAG04039.1
INSDC AAG04039.1
NCBI Locus Tag PA0650
protein_id(GenBank) gb|AAG04039.1|AE004500_5|gnl|PseudoCAP|PA0650
TIGR NTL03PA00651
UniParc UPI0000137592
UniProtKB Acc P20574
UniProtKB ID TRPD_PSEAE
UniRef100 UniRef100_B7V608
UniRef50 UniRef50_P00500
UniRef90 UniRef90_B7V608

Product

Feature Type CDS
Coding Frame 1
Product Name
anthranilate phosphoribosyltransferase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.43
Kyte-Doolittle Hydrophobicity Value 0.021
Molecular Weight (kDa) 37.4
Isoelectric Point (pI) 5.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 584 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000630 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0650
Search term: trpD

Human Homologs

References

DNA sequences and characterization of four early genes of the tryptophan pathway in Pseudomonas aeruginosa.
Essar DW, Eberly L, Han CY, Crawford IP
J Bacteriol 1990 Feb;172(2):853-66
PubMed ID: 2105306
Evolutionary differences in chromosomal locations of four early genes of the tryptophan pathway in fluorescent pseudomonads: DNA sequences and characterization of Pseudomonas putida trpE and trpGDC.
Essar DW, Eberly L, Crawford IP
J Bacteriol 1990 Feb;172(2):867-83
PubMed ID: 2404959