Pseudomonas aeruginosa PAO1, PA1107 (roeA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1107
Name
roeA
Replicon chromosome
Genomic location 1198750 - 1199946 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 6 transposon mutants in orthologs
CommentOverexpression of PA1107 increases pellicle formation.

Cross-References

RefSeq NP_249798.1
GI 15596304
Affymetrix PA1107_at
Entrez 879373
GenBank AAG04496.1
INSDC AAG04496.1
NCBI Locus Tag PA1107
protein_id(GenBank) gb|AAG04496.1|AE004541_1|gnl|PseudoCAP|PA1107
TIGR NTL03PA01108
UniParc UPI00000C524E
UniProtKB Acc Q9I4M8
UniProtKB ID Q9I4M8_PSEAE
UniRef100 UniRef100_W0YQ20
UniRef50 UniRef50_Q02IS4
UniRef90 UniRef90_Q02IS4

Product

Feature Type CDS
Coding Frame 1
Product Name
RoeA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.77
Kyte-Doolittle Hydrophobicity Value 0.110
Molecular Weight (kDa) 44.4
Isoelectric Point (pI) 8.34

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 457 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000167 (2758 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1107
Search term: roeA
Search term: RoeA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Specific control of Pseudomonas aeruginosa surface-associated behaviors by two c-di-GMP diguanylate cyclases.
Merritt JH, Ha DG, Cowles KN, Lu W, Morales DK, Rabinowitz J, Gitai Z, O'Toole GA
mBio 2010 Oct 19;1(4)
PubMed ID: 20978535
Analysis of Pseudomonas aeruginosa diguanylate cyclases and phosphodiesterases reveals a role for bis-(3'-5')-cyclic-GMP in virulence.
Kulasakara H, Lee V, Brencic A, Liberati N, Urbach J, Miyata S, Lee DG, Neely AN, Hyodo M, Hayakawa Y, Ausubel FM, Lory S
Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2839-44
PubMed ID: 16477007