Pseudomonas aeruginosa PAO1, PA1243

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1243
Name
Replicon chromosome
Genomic location 1345248 - 1347824 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249934.1
GI 15596440
Affymetrix PA1243_at
Entrez 881234
GenBank AAG04632.1
INSDC AAG04632.1
NCBI Locus Tag PA1243
protein_id(GenBank) gb|AAG04632.1|AE004553_9|gnl|PseudoCAP|PA1243
TIGR NTL03PA01244
UniParc UPI00000C52CC
UniProtKB Acc Q9I495
UniProtKB ID Q9I495_PSEAE
UniRef100 UniRef100_Q9I495
UniRef50 UniRef50_Q9I495
UniRef90 UniRef90_Q9I495

Product

Feature Type CDS
Coding Frame 1
Product Name
probable sensor/response regulator hybrid
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -28.11
Kyte-Doolittle Hydrophobicity Value -0.138
Molecular Weight (kDa) 93.3
Isoelectric Point (pI) 4.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 608 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001195 (914 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1243

Human Homologs

References

Characterization of the virA locus of Agrobacterium tumefaciens: a transcriptional regulator and host range determinant.
Leroux B, Yanofsky MF, Winans SC, Ward JE, Ziegler SF, Nester EW
EMBO J 1987 Apr;6(4):849-56
PubMed ID: 3595559
Rhizobium leguminosarum bv. viciae contains a second fnr/fixK-like gene and an unusual fixL homologue.
Patschkowski T, Schlüter A, Priefer UB
Mol Microbiol 1996 Jul;21(2):267-80
PubMed ID: 8858582