Pseudomonas aeruginosa PAO1, PA1271

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1271
Name
Replicon chromosome
Genomic location 1381804 - 1383654 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 13 transposon mutants in orthologs

Cross-References

RefSeq NP_249962.1
GI 15596468
Affymetrix PA1271_at
Entrez 881398
GenBank AAG04660.1
INSDC AAG04660.1
NCBI Locus Tag PA1271
protein_id(GenBank) gb|AAG04660.1|AE004557_1|gnl|PseudoCAP|PA1271
TIGR NTL03PA01272
UniParc UPI00000C52E0
UniProtKB Acc Q9I473
UniProtKB ID Q9I473_PSEAE
UniRef100 UniRef100_Q9I473
UniRef50 UniRef50_G2DBW8
UniRef90 UniRef90_A6V8T8

Product

Feature Type CDS
Coding Frame 1
Product Name
probable tonB-dependent receptor
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected using LC-MS/MS (67.57 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -10.84
Kyte-Doolittle Hydrophobicity Value -0.513
Molecular Weight (kDa) 67.6
Isoelectric Point (pI) 5.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 2
Outer Membrane Vesicle Class 1
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 344 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000897 (3061 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1271

Human Homologs

References

Point mutations in a conserved region (TonB box) of Escherichia coli outer membrane protein BtuB affect vitamin B12 transport.
Gudmundsdottir A, Bell PE, Lundrigan MD, Bradbeer C, Kadner RJ
J Bacteriol 1989 Dec;171(12):6526-33
PubMed ID: 2687240
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344