Pseudomonas aeruginosa PAO1, PA1922

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1922
Name
Synonym: cirA
Synonym: feuA
Replicon chromosome
Genomic location 2097491 - 2099452 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 13 transposon mutants in orthologs

Cross-References

RefSeq NP_250612.1
GI 15597118
Affymetrix PA1922_at
Entrez 882181
GenBank AAG05310.1
INSDC AAG05310.1
NCBI Locus Tag PA1922
protein_id(GenBank) gb|AAG05310.1|AE004618_4|gnl|PseudoCAP|PA1922
TIGR NTL03PA01922
UniParc UPI00000C60B5
UniProtKB Acc Q9I2I2
UniProtKB ID Q9I2I2_PSEAE
UniRef100 UniRef100_G3XCL2
UniRef50 UniRef50_A4VKH0
UniRef90 UniRef90_G3XCL2

Product

Feature Type CDS
Coding Frame 1
Product Name
probable TonB-dependent receptor
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -1.72
Kyte-Doolittle Hydrophobicity Value -0.562
Molecular Weight (kDa) 72.3
Isoelectric Point (pI) 6.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 341 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000897 (3061 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1922

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene.
Nau CD, Konisky J
J Bacteriol 1989 Feb;171(2):1041-7
PubMed ID: 2644220
Activation of expression of the Escherichia coli cir gene by an iron-independent regulatory mechanism involving cyclic AMP-cyclic AMP receptor protein complex.
Griggs DW, Kafka K, Nau CD, Konisky J
J Bacteriol 1990 Jun;172(6):3529-33
PubMed ID: 2160948
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994