Pseudomonas aeruginosa PAO1, PA2466 (foxA)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Synonym: foxA
Synonym: optS
Replicon chromosome
Genomic location 2782764 - 2785226 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 13 transposon mutants in orthologs


RefSeq NP_251156.1
GI 15597662
Affymetrix PA2466_at
Entrez 882859
GenBank AAG05854.1
INSDC AAG05854.1
NCBI Locus Tag PA2466
protein_id(GenBank) gb|AAG05854.1|AE004674_4|gnl|PseudoCAP|PA2466
UniParc UPI00000C56EB
UniProtKB Acc Q9I116
UniRef100 UniRef100_W0YQ97
UniRef50 UniRef50_Q4KKG1
UniRef90 UniRef90_B7V889


Feature Type CDS
Coding Frame 1
Product Name
Ferrioxamine receptor FoxA
Product Name Confidence: Class 1
Synonyms Ferrioxamine receptor FoxA
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -25.45
Kyte-Doolittle Hydrophobicity Value -0.425
Molecular Weight (kDa) 90.0
Isoelectric Point (pI) 4.77

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6I98 MEMBRANE PROTEIN 11/22/18 Structure of the ferrioxamine B transporter FoxA from Pseudomonas aeruginosa, apo state Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 100.0
6Z8A MEMBRANE PROTEIN 06/02/20 Outer membrane FoxA in complex with nocardamine Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.95 X-RAY DIFFRACTION 100.0
8B43 MEMBRANE PROTEIN 09/19/22 Crystal structure of ferrioxamine transporter Pseudomonas aeruginosa 2.49 X-RAY DIFFRACTION 100.0
6I96 MEMBRANE PROTEIN 11/22/18 Structure of the ferrioxamine B transporter FoxA from Pseudomonas aeruginosa in complex with ferrioxamine B Pseudomonas aeruginosa 1.85 X-RAY DIFFRACTION 100.0
6I97 MEMBRANE PROTEIN 11/22/18 Structure of the ferrioxamine B transporter FoxA from Pseudomonas aeruginosa in complex with ferrioxamine B and a C-terminal TonB fragment Pseudomonas aeruginosa 3.35 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 302 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000149 (2669 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA2466
Search term: foxA

Human Homologs


Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Ferrioxamine uptake in Yersinia enterocolitica: characterization of the receptor protein FoxA.
Bäumler AJ, Hantke K
Mol Microbiol 1992 May;6(10):1309-21
PubMed ID: 1640832
The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa.
Llamas MA, Sparrius M, Kloet R, Jiménez CR, Vandenbroucke-Grauls C, Bitter W
J Bacteriol 2006 Mar;188(5):1882-91
PubMed ID: 16484199