Pseudomonas aeruginosa PAO1, PA2473

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2473
Name
Replicon chromosome
Genomic location 2791220 - 2791864 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251163.1
GI 15597669
Affymetrix PA2473_at
DNASU PaCD00007073
Entrez 882919
GenBank AAG05861.1
INSDC AAG05861.1
NCBI Locus Tag PA2473
protein_id(GenBank) gb|AAG05861.1|AE004675_2|gnl|PseudoCAP|PA2473
TIGR NTL03PA02473
UniParc UPI00000C56F2
UniProtKB Acc Q9I109
UniProtKB ID Q9I109_PSEAE
UniRef100 UniRef100_W0YUG7
UniRef50 UniRef50_A0A085A7Q2
UniRef90 UniRef90_W0YUG7

Product

Feature Type CDS
Coding Frame 1
Product Name
maleylpyruvate isomerase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -0.20
Kyte-Doolittle Hydrophobicity Value -0.091
Molecular Weight (kDa) 23.9
Isoelectric Point (pI) 6.91

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6JWK ISOMERASE 04/20/19 Crystal structure of maleylpyruvate isomerase from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.86 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 205 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003079 (825 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2473

Human Homologs

Ensembl 110, assembly GRCh38.p14
glutathione S-transferase zeta 1 [Source:HGNC Symbol;Acc:HGNC:4643]
E-value: 1.9e-37
Percent Identity: 44.3
Ensembl 110, assembly GRCh38.p14
glutathione S-transferase zeta 1 [Source:HGNC Symbol;Acc:HGNC:4643]
E-value: 1.9e-37
Percent Identity: 44.3

References

Zeta, a novel class of glutathione transferases in a range of species from plants to humans.
Board PG, Baker RT, Chelvanayagam G, Jermiin LS
Biochem J 1997 Dec 15;328 ( Pt 3)(Pt 3):929-35
PubMed ID: 9396740
Structure and biochemical studies of a pseudomonad maleylpyruvate isomerase from Pseudomonas aeruginosa PAO1.
Hong H, Seo H, Kim KJ
Biochem Biophys Res Commun 2019 Jun 30;514(3):991-997
PubMed ID: 31092332