Pseudomonas aeruginosa PAO1, PA2477 (dsbE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2477
Name
dsbE
Replicon chromosome
Genomic location 2794973 - 2795809 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
CommentYu, Liang, et al. A novel copper-sensing two-component system for inducing Dsb gene expression in bacteria Science Bulletin (2021). https://doi.org/10.1016/j.scib.2021.03.003.

Cross-References

RefSeq NP_251167.1
GI 15597673
Affymetrix PA2477_at
DNASU PaCD00007074
Entrez 882174
GenBank AAG05865.1
INSDC AAG05865.1
NCBI Locus Tag PA2477
protein_id(GenBank) gb|AAG05865.1|AE004675_6|gnl|PseudoCAP|PA2477
TIGR NTL03PA02477
UniParc UPI00000C56F4
UniProtKB Acc Q9I105
UniProtKB ID Q9I105_PSEAE
UniRef100 UniRef100_A0A069PZC1
UniRef50 UniRef50_A6V4Y6
UniRef90 UniRef90_B7V878

Product

Feature Type CDS
Coding Frame 1
Product Name
thiol:disulfide interchange protein DsbE
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.65
Kyte-Doolittle Hydrophobicity Value 0.294
Molecular Weight (kDa) 30.2
Isoelectric Point (pI) 8.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 421 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003076 (508 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2477
Search term: dsbE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa.
Teitzel GM, Geddie A, De Long SK, Kirisits MJ, Whiteley M, Parsek MR
J Bacteriol 2006 Oct;188(20):7242-56
PubMed ID: 17015663