Pseudomonas aeruginosa PAO1, PA2478 (dsbD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2478
Name
dsbD
Synonym: dipZ2
Replicon chromosome
Genomic location 2795809 - 2797572 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs
CommentYu, Liang, et al. A novel copper-sensing two-component system for inducing Dsb gene expression in bacteria. Science Bulletin (2021). https://doi.org/10.1016/j.scib.2021.03.003.

Cross-References

RefSeq NP_251168.1
GI 15597674
Affymetrix PA2478_at
Entrez 882175
GenBank AAG05866.1
INSDC AAG05866.1
NCBI Locus Tag PA2478
protein_id(GenBank) gb|AAG05866.1|AE004675_7|gnl|PseudoCAP|PA2478
TIGR NTL03PA02478
UniParc UPI00001298FD
UniProtKB Acc Q9I104
UniProtKB ID DSBD2_PSEAE
UniRef100 UniRef100_Q9I104
UniRef50 UniRef50_Q9I104
UniRef90 UniRef90_Q9I104

Product

Feature Type CDS
Coding Frame 1
Product Name
thiol:disulfide interchange protein DsbD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 0.47
Kyte-Doolittle Hydrophobicity Value 0.407
Molecular Weight (kDa) 62.1
Isoelectric Point (pI) 7.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 317 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003075 (942 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2478
Search term: dsbD

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Specific thiol compounds complement deficiency in c-type cytochrome biogenesis in Escherichia coli carrying a mutation in a membrane-bound disulphide isomerase-like protein.
Sambongi Y, Ferguson SJ
FEBS Lett 1994 Oct 24;353(3):235-8
PubMed ID: 7957865
Disruption of the Pseudomonas aeruginosa dipZ gene, encoding a putative protein-disulfide reductase, leads to partial pleiotropic deficiency in c-type cytochrome biogenesis.
Page MD, Saunders NFW, Ferguson SJ
Microbiology (Reading) 1997 Oct;143 ( Pt 10):3111-3112
PubMed ID: 9353916
Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA.
Bushweller JH
J Mol Biol 2020 Aug 21;432(18):5091-5103
PubMed ID: 32305461