Pseudomonas aeruginosa PAO1, PA2491 (mexS)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA2491
|
| Name |
mexS
|
| Replicon | chromosome |
| Genomic location | 2806350 - 2807369 (- strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
Cross-References
| RefSeq | NP_251181.1 |
| GI | 15597687 |
| Affymetrix | PA2491_at |
| Entrez | 880416 |
| GenBank | AAG05879.1 |
| INSDC | AAG05879.1 |
| NCBI Locus Tag | PA2491 |
| protein_id(GenBank) | gb|AAG05879.1|AE004676_11|gnl|PseudoCAP|PA2491 |
| TIGR | NTL03PA02491 |
| UniParc | UPI00000C5701 |
| UniProtKB Acc | Q9I0Z1 |
| UniProtKB ID | Q9I0Z1_PSEAE |
| UniRef100 | UniRef100_Q9I0Z1 |
| UniRef50 | UniRef50_Q9I0Z1 |
| UniRef90 | UniRef90_Q9I0Z1 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
MexS
|
| Synonyms | |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -8.98 |
| Kyte-Doolittle Hydrophobicity Value | 0.055 |
| Molecular Weight (kDa) | 36.8 |
| Isoelectric Point (pI) | 5.26 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| MexS | MexS is a suppressor of MexT, which is an activator of the multidrug pump MexEF-OprN. Mutations in MexS lead to multidrug resistance. [PMID:11040437, PMID:15687188, PMID:26833155] | ARO:3000813 | protein overexpression model | Strict | 672.5 | 99.71 | 3.2.4 |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 495 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG003064 (541 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA2491
Search term: mexS
Search term: MexS
|
Human Homologs
|
Ensembl
107, assembly
GRCh38.p13
|
vesicle amine transport 1 [Source:HGNC Symbol;Acc:HGNC:16919]
E-value:
4.5e-25
Percent Identity:
28.2
|
References
|
Mutations in PA2491 (mexS) promote MexT-dependent mexEF-oprN expression and multidrug resistance in a clinical strain of Pseudomonas aeruginosa.
Sobel ML, Neshat S, Poole K
J. Bacteriol. 2005 Feb;187(4):1246-53
PubMed ID: 15687188
|