Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2494
|
Name |
mexF
|
Replicon | chromosome |
Genomic location | 2810009 - 2813197 (+ strand) |
Transposon Mutants | 11 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 8 transposon mutants in orthologs |
RefSeq | NP_251184.1 |
GI | 15597690 |
Affymetrix | PA2494_mexF_at |
Entrez | 882884 |
GenBank | AAG05882.1 |
INSDC | AAG05882.1 |
NCBI Locus Tag | PA2494 |
protein_id(GenBank) | gb|AAG05882.1|AE004676_14|gnl|PseudoCAP|PA2494 |
TIGR | NTL03PA02494 |
UniParc | UPI00000C5704 |
UniProtKB Acc | Q9I0Y8 |
UniProtKB ID | Q9I0Y8_PSEAE |
UniRef100 | UniRef100_Q9I0Y8 |
UniRef50 | UniRef50_Q8EBL9 |
UniRef90 | UniRef90_Q9I0Y8 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexF
|
Synonyms |
RND multidrug efflux transporter MexF |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -11.43 |
Kyte-Doolittle Hydrophobicity Value | 0.284 |
Molecular Weight (kDa) | 115.5 |
Isoelectric Point (pI) | 5.41 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexF | MexF is the multidrug inner membrane transporter of the MexEF-OprN complex. mexF corresponds to 2 loci in Pseudomonas aeruginosa PAO1 (gene name: mexF/mexB) and 4 loci in Pseudomonas aeruginosa LESB58 (gene name: mexD/mexB). [PMID:10515918] | ARO:3000804 | protein homolog model | Perfect | 2016.5 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 488 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000417 (2093 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2494
Search term: mexF
|
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
|
Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
Köhler T, Michéa-Hamzehpour M, Henze U, Gotoh N, Curty LK, Pechère JC
Mol Microbiol 1997 Jan;23(2):345-54
PubMed ID: 9044268
|