Pseudomonas aeruginosa PAO1, PA3166 (pheA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3166
Name
pheA
Replicon chromosome
Genomic location 3554157 - 3555254 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251856.1
GI 15598362
Affymetrix PA3166_pheA_at
DNASU PaCD00007393
Entrez 882699
GenBank AAG06554.1
INSDC AAG06554.1
NCBI Locus Tag PA3166
protein_id(GenBank) gb|AAG06554.1|AE004740_7|gnl|PseudoCAP|PA3166
TIGR NTL03PA03166
UniParc UPI00000C5931
UniProtKB Acc Q9HZ67
UniProtKB ID PHEA_PSEAE
UniRef100 UniRef100_Q9HZ67
UniRef50 UniRef50_Q9HZ67
UniRef90 UniRef90_Q9HZ67

Product

Feature Type CDS
Coding Frame 1
Product Name
chorismate mutase
Product Name Confidence: Class 2
Synonyms prephenate dehydratase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.74
Kyte-Doolittle Hydrophobicity Value -0.227
Molecular Weight (kDa) 40.6
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 592 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002449 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3166
Search term: pheA
Search term: chorismate mutase

Human Homologs

References

Cloning, sequencing, and expression of the P-protein gene (pheA) of Pseudomonas stutzeri in Escherichia coli: implications for evolutionary relationships in phenylalanine biosynthesis.
Fischer RS, Zhao G, Jensen RA
J Gen Microbiol 1991 Jun;137(6):1293-301
PubMed ID: 1919506
A probable mixed-function supraoperon in Pseudomonas exhibits gene organization features of both intergenomic conservation and gene shuffling.
Xie G, Bonner CA, Jensen RA
J Mol Evol 1999 Jul;49(1):108-21
PubMed ID: 10368439