Pseudomonas aeruginosa PAO1, PA3563 (fruR)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Replicon chromosome
Genomic location 3994739 - 3995728 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs


RefSeq NP_252253.1
GI 15598759
Affymetrix PA3563_fruR_at
DNASU PaCD00007562
Entrez 878245
GenBank AAG06951.1
INSDC AAG06951.1
NCBI Locus Tag PA3563
protein_id(GenBank) gb|AAG06951.1|AE004777_4|gnl|PseudoCAP|PA3563
UniParc UPI00000C5A6D
UniProtKB Acc Q9HY54
UniRef100 UniRef100_Q9HY54
UniRef50 UniRef50_W6QYU1
UniRef90 UniRef90_Q9HY54


Feature Type CDS
Coding Frame 1
Product Name
fructose transport system repressor FruR
Product Name Confidence: Class 2
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.43
Kyte-Doolittle Hydrophobicity Value -0.133
Molecular Weight (kDa) 36.4
Isoelectric Point (pI) 6.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 371 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002103 (522 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA3563
Search term: fruR

Human Homologs


Molecular cloning, nucleotide sequence, and expression of shl, a new gene in the 2-minute region of the genetic map of Escherichia coli.
Leclerc G, Noël G, Drapeau GR
J Bacteriol 1990 Aug;172(8):4696-700
PubMed ID: 2198273
Nucleotide sequence of the ilvH-fruR gene region of Escherichia coli K12 and Salmonella typhimurium LT2.
Jahreis K, Postma PW, Lengeler JW
Mol Gen Genet 1991 Apr;226(1-2):332-6
PubMed ID: 1851954
The catabolite repressor/activator (Cra) protein of enteric bacteria.
Saier MH Jr, Ramseier TM
J Bacteriol 1996 Jun;178(12):3411-7
PubMed ID: 8655535
Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR.
Penin F, Geourjon C, Montserret R, Böckmann A, Lesage A, Yang YS, Bonod-Bidaud C, Cortay JC, Nègre D, Cozzone AJ, Deléage G
J Mol Biol 1997 Jul 18;270(3):496-510
PubMed ID: 9237914
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503