Pseudomonas aeruginosa PAO1, PA4626 (hprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4626
Name
hprA
Replicon chromosome
Genomic location 5193196 - 5194167 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253316.1
GI 15599822
Affymetrix PA4626_hprA_at
DNASU PaCD00008005
Entrez 881182
GenBank AAG08014.1
INSDC AAG08014.1
NCBI Locus Tag PA4626
protein_id(GenBank) gb|AAG08014.1|AE004877_1|gnl|PseudoCAP|PA4626
TIGR NTL03PA04627
UniParc UPI00000C5D96
UniProtKB Acc Q9HVG5
UniProtKB ID Q9HVG5_PSEAE
UniRef100 UniRef100_Q9HVG5
UniRef50 UniRef50_Q4K6D3
UniRef90 UniRef90_Q9HVG5

Product

Feature Type CDS
Coding Frame 1
Product Name
glycerate dehydrogenase
Product Name Confidence: Class 2
Synonyms hydroxypyruvate reductase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.74
Kyte-Doolittle Hydrophobicity Value 0.065
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 6.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000893 (1006 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4626
Search term: hprA

Human Homologs

Ensembl 110, assembly GRCh38.p14
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.4e-34
Percent Identity: 33.6
Ensembl 110, assembly GRCh38.p14
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.4e-34
Percent Identity: 33.6
Ensembl 110, assembly GRCh38.p14
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.4e-34
Percent Identity: 33.6
Ensembl 110, assembly GRCh38.p14
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.4e-34
Percent Identity: 33.6
Ensembl 110, assembly GRCh38.p14
phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923]
E-value: 1.4e-34
Percent Identity: 33.6

References

Purification and characterization of hydroxypyruvate reductase from the facultative methylotroph Methylobacterium extorquens AM1.
Chistoserdova LV, Lidstrom ME
J Bacteriol 1991 Nov;173(22):7228-32
PubMed ID: 1657886
Cloning, mutagenesis, and physiological effect of a hydroxypyruvate reductase gene from Methylobacterium extorquens AM1.
Chistoserdova LV, Lidstrom ME
J Bacteriol 1992 Jan;174(1):71-7
PubMed ID: 1729225