Pseudomonas aeruginosa PAO1, PA5435

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA5435
Name
Synonym: oadA
Replicon chromosome
Genomic location 6116493 - 6118316 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_254122.1
GI 15600628
Affymetrix PA5435_at
Entrez 877876
GenBank AAG08820.1
INSDC AAG08820.1
NCBI Locus Tag PA5435
protein_id(GenBank) gb|AAG08820.1|AE004956_4|gnl|PseudoCAP|PA5435
TIGR NTL03PA05436
UniParc UPI00000C6004
UniProtKB Acc Q9HTD1
UniProtKB ID Q9HTD1_PSEAE
UniRef100 UniRef100_W0Z2K2
UniRef50 UniRef50_Q4K3G8
UniRef90 UniRef90_A0A024HAF2

Product

Feature Type CDS
Coding Frame 1
Product Name
probable transcarboxylase subunit
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected by iTRAQ (PMID:21863142).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -10.72
Kyte-Doolittle Hydrophobicity Value -0.165
Molecular Weight (kDa) 66.1
Isoelectric Point (pI) 5.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 507 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004985 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5435

Human Homologs

Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3
Ensembl 97, assembly GRCh38.p12
pyruvate carboxylase [Source:HGNC Symbol;Acc:HGNC:8636]
E-value: 2.5e-78
Percent Identity: 32.3

References

The sodium ion translocating oxalacetate decarboxylase of Klebsiella pneumoniae. Sequence of the biotin-containing alpha-subunit and relationship to other biotin-containing enzymes.
Schwarz E, Oesterhelt D, Reinke H, Beyreuther K, Dimroth P
J Biol Chem 1988 Jul 15;263(20):9640-5
PubMed ID: 2454915
An oxaloacetate decarboxylase homologue protein influences the intracellular survival of Legionella pneumophila.
Jain B, Brand BC, Lück PC, Di Berardino M, Dimroth P, Hacker J
FEMS Microbiol. Lett. 1996 Dec;145(2):273-9
PubMed ID: 8961567
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011 ;2
PubMed ID: 21863142