Pseudomonas aeruginosa PAO1, PA0024 (hemF)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0024
|
| Name |
hemF
|
| Replicon | chromosome |
| Genomic location | 25736 - 26653 (+ strand) |
| Transposon Mutants | 1 transposon mutants in PAO1 |
Cross-References
| RefSeq | NP_248714.1 |
| GI | 15595222 |
| Affymetrix | PA0024_hemF_at |
| Entrez | 880901 |
| GenBank | AAG03414.1 |
| INSDC | AAG03414.1 |
| NCBI Locus Tag | PA0024 |
| protein_id(GenBank) | gb|AAG03414.1|AE004442_1|gnl|PseudoCAP|PA0024 |
| TIGR | NTL03PA00025 |
| UniParc | UPI000012C4B5 |
| UniProtKB Acc | P43898 |
| UniProtKB ID | HEM6_PSEAE |
| UniRef100 | UniRef100_Q02V57 |
| UniRef50 | UniRef50_P84155 |
| UniRef90 | UniRef90_A6UX86 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
coproporphyrinogen III oxidase, aerobic
|
| Synonyms | |
| Evidence for Translation |
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | -7.53 |
| Kyte-Doolittle Hydrophobicity Value | -0.507 |
| Molecular Weight (kDa) | 34.8 |
| Isoelectric Point (pI) | 5.78 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 279 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000024 (554 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0024
Search term: hemF
Search term: coproporphyrinogen III oxidase, aerobic
|
Human Homologs
|
Ensembl
107, assembly
GRCh38.p13
|
coproporphyrinogen oxidase [Source:HGNC Symbol;Acc:HGNC:2321]
E-value:
4.3e-75
Percent Identity:
44.4
|
References
|
An oxygen-dependent coproporphyrinogen oxidase encoded by the hemF gene of Salmonella typhimurium.
Xu K, Elliott T
J. Bacteriol. 1993 Aug;175(16):4990-9
PubMed ID: 8349542
|
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|