Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
Locus Tag |
PA14_00560
|
Name |
exoT
|
Replicon | chromosome |
Genomic location | 57148 - 58476 (+ strand) |
Transposon Mutants | 2 transposon mutants in UCBPP-PA14 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | YP_788201.1 |
GI | 116053766 |
Entrez | 4381738 |
INSDC | ABJ15002.1 |
NCBI Locus Tag | PA14_00560 |
UniParc | UPI0000E44880 |
UniProtKB Acc | Q02V35 |
UniProtKB ID | Q02V35_PSEAB |
UniRef100 | UniRef100_Q02V35 |
UniRef50 | UniRef50_Q93Q17 |
UniRef90 | UniRef90_Q9I788 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
exoenzyme T
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | -9.33 |
Kyte-Doolittle Hydrophobicity Value | -0.313 |
Molecular Weight (kDa) | 46.8 |
Isoelectric Point (pI) | 5.49 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6JNP | TOXIN | 03/17/19 | Structure of ExoT-SpcS Complex from Pseudomonas aeruginosa in 2.2 Angstrom | Pseudomonas aeruginosa | 2.261 | X-RAY DIFFRACTION | 98.2 |
4JMF | TOXIN/CHAPERONE | 03/14/13 | Crystal structure of ExoT (residues 28 -77)- SpcS complex from Pseudomonas aeruginosa at 2.1 angstrom | Pseudomonas aeruginosa | 2.099 | X-RAY DIFFRACTION | 100.0 |
6GNN | TOXIN | 05/31/18 | Exoenzyme T from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form bound to STO1101 | Homo sapiens; Pseudomonas aeruginosa PAO1 | 3.79 | X-RAY DIFFRACTION | 99.5 |
Source 1 | |
Database | PseudoCAP |
Category | T3SS translocated effectors |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Galleria mellonella |
Notes | |
Infection model | Galleria mellonella killing assay |
Reference | 12704110 |
Source 2 | |
Database | Victors : 4411 |
Category | T3SS translocated effectors |
Evidence |
ECO:0000314
direct assay evidence used in manual assertion
|
Host Organism | Cricetulus griseus |
Notes | exoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis |
Reference | 10992524 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 8 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG000044 (294 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_00560
Search term: exoT
Search term: exoenzyme T
|