Pseudomonas aeruginosa UCBPP-PA14, PA14_01710

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_01710
Name
Synonym: ahpC1
Replicon chromosome
Genomic location 156164 - 156727 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentAhpC1 is key to neutralize the physiological organic peroxide, urate hydroperoxide [PMID:34315109]
CommentAhpC1 increases P. aeruginosa virulence [PMID:34315109]
CommentReferred to as AhpC1 in PMID:PA14_01710
Comment
CommentAhpC1 efficiently scavenges oxidants from inflammatory oxidative burst [PMID:34315109]
CommentAhpC1 provides a mechanism for P. aeruginosa subverting immune system [PMID:34315109]

Cross-References

RefSeq YP_788296.1
GI 116053859
Entrez 4384255
INSDC ABJ15095.1
NCBI Locus Tag PA14_01710
UniParc UPI00000C4F5B
UniProtKB Acc Q02UU0
UniProtKB ID AHPC_PSEAB
UniRef100 UniRef100_Q02UU0
UniRef50 UniRef50_Q02UU0
UniRef90 UniRef90_Q02UU0

Product

Feature Type CDS
Coding Frame 1
Product Name
alkyl hydroperoxide reductase
Synonyms
Evidence for Translation
Charge (pH 7) -3.14
Kyte-Doolittle Hydrophobicity Value -0.182
Molecular Weight (kDa) 20.5
Isoelectric Point (pI) 6.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 590 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000137 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_01710

Human Homologs

Ensembl 110, assembly GRCh38.p14
peroxiredoxin 3 [Source:HGNC Symbol;Acc:HGNC:9354]
E-value: 8.7e-34
Percent Identity: 42.5

References

Peroxiredoxin AhpC1 protects Pseudomonas aeruginosa against the inflammatory oxidative burst and confers virulence.
Rocha LS, Silva BPD, Correia TML, Silva RPD, Meireles DA, Pereira R, Netto LES, Meotti FC, Queiroz RF
Redox Biol 2021 Oct;46:102075
PubMed ID: 34315109