Pseudomonas aeruginosa UCBPP-PA14, PA14_02550 (mdcA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_02550
Name
mdcA
Replicon chromosome
Genomic location 227383 - 229047 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_788359.1
GI 116053921
Entrez 4383600
INSDC ABJ15157.1
NCBI Locus Tag PA14_02550
UniParc UPI000045D3AF
UniProtKB Acc Q02UM7
UniProtKB ID Q02UM7_PSEAB
UniRef100 UniRef100_Q02UM7
UniRef50 UniRef50_O06924
UniRef90 UniRef90_Q9I6T0

Product

Feature Type CDS
Coding Frame 1
Product Name
malonate decarboxylase subunit alpha
Synonyms
Evidence for Translation
Charge (pH 7) -4.21
Kyte-Doolittle Hydrophobicity Value -0.183
Molecular Weight (kDa) 61.5
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5VIT TRANSFERASE 04/17/17 Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with malonate Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 2.203 X-RAY DIFFRACTION 99.6
5VJ1 TRANSFERASE 04/18/17 Crystal structure of a Pseudomonas malonate decarboxylase hetero-tetramer in complex with coenzyme A Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1); Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 2.995 X-RAY DIFFRACTION 99.6

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 59 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000207 (477 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_02550
Search term: mdcA

Human Homologs

References

No references are associated with this feature.