Pseudomonas aeruginosa UCBPP-PA14, PA14_57370 (murD)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_57370
Name	murD
Replicon	chromosome
Genomic location	5110888 - 5112234 (- strand)
Transposon Mutants in orthologs	1 transposon mutants in orthologs

Cross-References

RefSeq	YP_792760.1
GI	116052448
EC Number	6.3.2.9
Entrez	4382518
INSDC	ABJ13684.1
NCBI Locus Tag	PA14_57370
UniParc	UPI000039637A
UniProtKB Acc	Q02H26
UniProtKB ID	Q02H26_PSEAB
UniRef100	UniRef100_Q02H26
UniRef50	UniRef50_Q9HVZ9
UniRef90	UniRef90_Q9HVZ9

Product

Feature Type	CDS
Coding Frame	1
Product Name	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.27
Kyte-Doolittle Hydrophobicity Value	0.118
Molecular Weight (kDa)	48.1
Isoelectric Point (pI)	5.51

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
7U35	LIGASE	02/25/22	Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with ADP	Pseudomonas aeruginosa PAO1	1.95	X-RAY DIFFRACTION	99.8
7SY9	LIGASE	11/24/21	Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.75	X-RAY DIFFRACTION	99.8
8DP2	LIGASE	07/14/22	Crystal Structure of UDP-N-acetylmuramoylalanine--D-glutamate ligase (MurD) from Pseudomonas aeruginosa PAO1 in complex with UMA (Uridine-5'-diphosphate-N-acetylmuramoyl-L-Alanine)	Pseudomonas aeruginosa PAO1	1.6	X-RAY DIFFRACTION	99.8

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 574 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004004 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_57370 Search term: murD Search term: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase

Human Homologs

References