Pseudomonas aeruginosa PAO1, PA2832 (tpm)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2832
Name
tpm
Replicon chromosome
Genomic location 3185161 - 3185817 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251522.1
GI 15598028
Affymetrix PA2832_tpm_at
DNASU PaCD00007230
Entrez 882816
GenBank AAG06220.1
INSDC AAG06220.1
NCBI Locus Tag PA2832
protein_id(GenBank) gb|AAG06220.1|AE004710_2|gnl|PseudoCAP|PA2832
TIGR NTL03PA02832
UniParc UPI00000C5830
UniProtKB Acc Q9I011
UniProtKB ID TPMT_PSEAE
UniRef100 UniRef100_Q9I011
UniRef50 UniRef50_Q9I011
UniRef90 UniRef90_Q9I011

Product

Feature Type CDS
Coding Frame 1
Product Name
thiopurine methyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.38
Kyte-Doolittle Hydrophobicity Value -0.139
Molecular Weight (kDa) 24.9
Isoelectric Point (pI) 4.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 91 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002735 (520 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2832
Search term: tpm

Human Homologs

Ensembl 110, assembly GRCh38.p14
thiopurine S-methyltransferase [Source:HGNC Symbol;Acc:HGNC:12014]
E-value: 6.2e-23
Percent Identity: 30.9

References

A tellurite-resistance genetic determinant from phytopathogenic pseudomonads encodes a thiopurine methyltransferase: evidence of a widely-conserved family of methyltransferases.
Cournoyer B, Watanabe S, Vivian A
Biochim Biophys Acta 1998 Apr 29;1397(2):161-8
PubMed ID: 9565678