Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2967
|
Name |
fabG
|
Replicon | chromosome |
Genomic location | 3325379 - 3326122 (- strand) |
RefSeq | NP_251657.1 |
GI | 15598163 |
Affymetrix | PA2967_fabG_at |
DNASU | PaCD00007294 |
Entrez | 880433 |
GenBank | AAG06355.1 |
INSDC | AAG06355.1 |
NCBI Locus Tag | PA2967 |
protein_id(GenBank) | gb|AAG06355.1|AE004722_11|gnl|PseudoCAP|PA2967 |
TIGR | NTL03PA02967 |
UniParc | UPI000012A462 |
UniProtKB Acc | O54438 |
UniProtKB ID | FABG_PSEAE |
UniRef100 | UniRef100_O54438 |
UniRef50 | UniRef50_P0AEK2 |
UniRef90 | UniRef90_O54438 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
3-oxoacyl-[acyl-carrier-protein] reductase
|
Synonyms |
FabG protein beta-ketoacyl acyl carrier protein reductase |
Evidence for Translation |
Detected by two-dimensional gel electrophoresis and protein mass mapping(PMID:21863142).
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -0.52 |
Kyte-Doolittle Hydrophobicity Value | 0.176 |
Molecular Weight (kDa) | 25.6 |
Isoelectric Point (pI) | 6.56 |
Individual Mappings | |
Additional evidence for subcellular localization |
Detetected in a periplasmic protein preparation by spheroplasting by osmotic shock.(PMID:19333994)
|
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
4BO2 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9A resolution | PSEUDOMONAS AERUGINOSA | 1.9 | X-RAY DIFFRACTION | 100.0 |
4BO8 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7A resolution | PSEUDOMONAS AERUGINOSA | 2.7 | X-RAY DIFFRACTION | 100.0 |
4BO7 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(2,3-dihydro-1H-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6A resolution | PSEUDOMONAS AERUGINOSA | 2.6 | X-RAY DIFFRACTION | 100.0 |
4BO6 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8A resolution | PSEUDOMONAS AERUGINOSA | 2.8 | X-RAY DIFFRACTION | 100.0 |
4BO9 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9A resolution | PSEUDOMONAS AERUGINOSA | 2.9 | X-RAY DIFFRACTION | 100.0 |
4BNZ | OXIDOREDUCTASE | 05/17/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-methyl-N-phenylindole- 3-carboxamide at 2.5A resolution | PSEUDOMONAS AERUGINOSA | 2.5 | X-RAY DIFFRACTION | 100.0 |
4BO3 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(3-(trifluoromethyl) anilino)pyridine-3-sulfonamide at 2.5A resolution | PSEUDOMONAS AERUGINOSA | 2.5 | X-RAY DIFFRACTION | 100.0 |
4BNY | OXIDOREDUCTASE | 05/17/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8A resolution | PSEUDOMONAS AERUGINOSA | 1.8 | X-RAY DIFFRACTION | 100.0 |
4BO0 | OXIDOREDUCTASE | 05/17/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4A resolution | PSEUDOMONAS AERUGINOSA | 2.4 | X-RAY DIFFRACTION | 100.0 |
4BO1 | OXIDOREDUCTASE | 05/18/13 | Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with N-(4-chloro-2,5- dimethoxyphenyl)quinoline-8-carboxamide at 2.2A resolution | PSEUDOMONAS AERUGINOSA | 2.2 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 652 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG002615 (536 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2967
Search term: fabG
Search term: 3-oxoacyl-[acyl-carrier-protein] reductase
|
Ensembl
110, assembly
GRCh38.p14
|
carbonyl reductase 4 [Source:HGNC Symbol;Acc:HGNC:25891]
E-value:
4.4e-41
Percent Identity:
42.7
|
The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes.
Rawlings M, Cronan JE Jr
J Biol Chem 1992 Mar 25;267(9):5751-4
PubMed ID: 1556094
|
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
|
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142
|
Beta-ketoacyl acyl carrier protein reductase (FabG) activity of the fatty acid biosynthetic pathway is a determining factor of 3-oxo-homoserine lactone acyl chain lengths.
Hoang TT, Sullivan SA, Cusick JK, Schweizer HP
Microbiology (Reading) 2002 Dec;148(Pt 12):3849-3856
PubMed ID: 12480888
|
Characterization of 3-Oxacyl-Acyl Carrier Protein Reductase Homolog Genes in Pseudomonas aeruginosa PAO1.
Guo QQ, Zhang WB, Zhang C, Song YL, Liao YL, Ma JC, Yu YH, Wang HH
Front Microbiol 2019;10:1028
PubMed ID: 31231314
|