Pseudomonas aeruginosa PAO1, PA3326 (clpP2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3326
Name
clpP2
Replicon chromosome
Genomic location 3729471 - 3730076 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252016.1
GI 15598522
Affymetrix PA3326_at
Entrez 882491
GenBank AAG06714.1
INSDC AAG06714.1
NCBI Locus Tag PA3326
protein_id(GenBank) gb|AAG06714.1|AE004755_1|gnl|PseudoCAP|PA3326
TIGR NTL03PA03326
UniParc UPI0000127AFA
UniProtKB Acc Q9HYR9
UniProtKB ID CLPP2_PSEAE
UniRef100 UniRef100_Q9HYR9
UniRef50 UniRef50_Q8UD57
UniRef90 UniRef90_Q9HYR9

Product

Feature Type CDS
Coding Frame 1
Product Name
ClpP2
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.04
Kyte-Doolittle Hydrophobicity Value -0.249
Molecular Weight (kDa) 22.1
Isoelectric Point (pI) 5.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7M1L HYDROLASE 03/13/21 Crystal structure of Pseudomonas aeruginosa ClpP2 Pseudomonas aeruginosa 2 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 581 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002297 (303 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3326
Search term: clpP2
Search term: ClpP2

Human Homologs

Ensembl 110, assembly GRCh38.p14
caseinolytic mitochondrial matrix peptidase proteolytic subunit [Source:HGNC Symbol;Acc:HGNC:2084]
E-value: 1.6e-28
Percent Identity: 39.5

References

ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa.
Qiu D, Eisinger VM, Head NE, Pier GB, Yu HD
Microbiology (Reading) 2008 Jul;154(Pt 7):2119-2130
PubMed ID: 18599839