Pseudomonas aeruginosa PAO1, PA3980

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3980
Name
Synonym: yleA
Synonym: miaB
Replicon chromosome
Genomic location 4459879 - 4461219 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252669.1
GI 15599175
Affymetrix PA3980_at
Entrez 878903
GenBank AAG07367.1
INSDC AAG07367.1
NCBI Locus Tag PA3980
protein_id(GenBank) gb|AAG07367.1|AE004816_3|gnl|PseudoCAP|PA3980
TIGR NTL03PA03980
UniParc UPI000013974E
UniProtKB Acc Q51470
UniProtKB ID MIAB_PSEAE
UniRef100 UniRef100_Q02SE8
UniRef50 UniRef50_A8AJE9
UniRef90 UniRef90_Q02SE8

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.09
Kyte-Doolittle Hydrophobicity Value -0.267
Molecular Weight (kDa) 50.0
Isoelectric Point (pI) 5.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 640 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001701 (487 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3980

Human Homologs

Ensembl 110, assembly GRCh38.p14
CDK5 regulatory subunit associated protein 1 [Source:HGNC Symbol;Acc:HGNC:15880]
E-value: 3.1e-77
Percent Identity: 37.9
Ensembl 110, assembly GRCh38.p14
CDK5 regulatory subunit associated protein 1 [Source:HGNC Symbol;Acc:HGNC:15880]
E-value: 3.1e-77
Percent Identity: 37.9

References

Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli.
Esberg B, Leung HC, Tsui HC, Björk GR, Winkler ME
J Bacteriol 1999 Dec;181(23):7256-65
PubMed ID: 10572129