Pseudomonas aeruginosa PAO1, PA0065

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0065
Name
Replicon chromosome
Genomic location 77432 - 78097 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248755.1
GI 15595263
Affymetrix PA0065_at
Entrez 878495
GenBank AAG03455.1
INSDC AAG03455.1
NCBI Locus Tag PA0065
protein_id(GenBank) gb|AAG03455.1|AE004446_3|gnl|PseudoCAP|PA0065
TIGR NTL03PA00066
UniParc UPI00000C4F12
UniProtKB Acc Q9I767
UniProtKB ID 5NTD_PSEAE
UniRef100 UniRef100_Q9I767
UniRef50 UniRef50_Q9I767
UniRef90 UniRef90_Q9I767

Product

Feature Type CDS
Coding Frame 1
Product Name
haloacid dehalogenase (HAD) family hydrolase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.24
Kyte-Doolittle Hydrophobicity Value -0.253
Molecular Weight (kDa) 25.0
Isoelectric Point (pI) 6.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 406 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000064 (514 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0065

Human Homologs

References

<i>pruR</i> and PA0065 Genes Are Responsible for Decreasing Antibiotic Tolerance by Autoinducer Analog-1 (AIA-1) in <i>Pseudomonas aeruginosa</i>.
Pahlevi MR, Murakami K, Hiroshima Y, Murakami A, Fujii H
Antibiotics (Basel) 2022 Jun 6;11(6)
PubMed ID: 35740179