Pseudomonas aeruginosa PAO1, PA0162 (opdC)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
Locus Tag
Synonym: opdC
Replicon chromosome
Genomic location 184594 - 185928 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs


RefSeq NP_248852.1
GI 15595360
Affymetrix PA0162_at
Entrez 879518
GenBank AAG03552.1
INSDC AAG03552.1
NCBI Locus Tag PA0162
protein_id(GenBank) gb|AAG03552.1|AE004454_4|gnl|PseudoCAP|PA0162
UniParc UPI00000C4F71
UniProtKB Acc Q9I6X0
UniRef100 UniRef100_Q9I6X0
UniRef50 UniRef50_V6A7C8
UniRef90 UniRef90_V6A7C8


Feature Type CDS
Coding Frame 1
Product Name
histidine porin OpdC
Product Name Confidence: Class 1
Synonyms OccD2
histidine porin OpdC
Evidence for Translation
Detected using LC-MS/MS (48.86 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -15.39
Kyte-Doolittle Hydrophobicity Value -0.488
Molecular Weight (kDa) 48.9
Isoelectric Point (pI) 4.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Vesicle Class 1
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SY9 MEMBRANE PROTEIN 07/16/11 Crystal structure of Pseudomonas aeruginosa OccD2 (OpdC) Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 99.8

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 24 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000160 (436 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0162
Search term: opdC

Human Homologs


Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344
Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics.
Salvà-Serra F, Jaén-Luchoro D, Marathe NP, Adlerberth I, Moore ERB, Karlsson R
Front Microbiol 2022;13:1089140
PubMed ID: 36845973
Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.
Tamber S, Ochs MM, Hancock RE
J Bacteriol 2006 Jan;188(1):45-54
PubMed ID: 16352820
OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity.
Liu J, Eren E, Vijayaraghavan J, Cheneke BR, Indic M, van den Berg B, Movileanu L
Biochemistry 2012 Mar 20;51(11):2319-30
PubMed ID: 22369314