Pseudomonas aeruginosa PAO1, PA0372

Cytoplasmic Membrane
Outer Membrane
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 416009 - 417406 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs


RefSeq NP_249063.1
GI 15595569
Affymetrix PA0372_at
Entrez 883000
GenBank AAG03761.1
INSDC AAG03761.1
NCBI Locus Tag PA0372
protein_id(GenBank) gb|AAG03761.1|AE004475_3|gnl|PseudoCAP|PA0372
UniParc UPI00000C5030
UniProtKB Acc Q9I6C2
UniRef100 UniRef100_Q9I6C2
UniRef50 UniRef50_W6V377
UniRef90 UniRef90_Q9I6C2


Feature Type CDS
Coding Frame 1
Product Name
probable zinc protease
Product Name Confidence: Class 3
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Detected using LC-MS/MS (51.97 kDa, PMID:21751344)
Verified using two-dimensional gel electrophoresis, MALDI-TOF MS and peptide mass mapping(pI:6.2, molecular weight:51.9, PMID:21674802)
Charge (pH 7) -2.08
Kyte-Doolittle Hydrophobicity Value -0.341
Molecular Weight (kDa) 51.9
Isoelectric Point (pI) 6.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4NNZ HYDROLASE 11/19/13 Subunit PA0372 of heterodimeric zinc protease PA0371-PA0372 PSEUDOMONAS AERUGINOSA 2.478 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 530 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000363 (550 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA0372

Human Homologs


Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.
Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ
Proteomics 2011 Aug;11(15):3056-69
PubMed ID: 21674802
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344