Pseudomonas aeruginosa PAO1, PA0682 (hxcX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0682
Name
hxcX
Replicon chromosome
Genomic location 739176 - 740141 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentNo glutamate residue in position +5. No prokaryotic N-terminal methylation site as with classical pilins or pseudopilins. Hxc proteins are involved in alkaline phosphatase secretion. Belongs to the GspK family (general secretory pathway).

Cross-References

RefSeq NP_249373.1
GI 15595879
Affymetrix PA0682_at
DNASU PaCD00006313
Entrez 880818
GenBank AAG04071.1
INSDC AAG04071.1
NCBI Locus Tag PA0682
protein_id(GenBank) gb|AAG04071.1|AE004503_9|gnl|PseudoCAP|PA0682
TIGR NTL03PA00683
UniParc UPI00000C50FB
UniProtKB Acc Q9I5P3
UniProtKB ID Q9I5P3_PSEAE
UniRef100 UniRef100_Q9I5P3
UniRef50 UniRef50_Q4KD23
UniRef90 UniRef90_Q02HH4

Product

Feature Type CDS
Coding Frame 1
Product Name
HxcX
Product Name Confidence: Class 1
Synonyms HxcX atypical pseudopilin
Evidence for Translation
Charge (pH 7) 12.22
Kyte-Doolittle Hydrophobicity Value -0.280
Molecular Weight (kDa) 36.0
Isoelectric Point (pI) 11.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 52 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000661 (723 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0682
Search term: hxcX
Search term: HxcX

Human Homologs

References

The secretion apparatus of Pseudomonas aeruginosa: identification of a fifth pseudopilin, XcpX (GspK family).
Bleves S, Voulhoux R, Michel G, Lazdunski A, Tommassen J, Filloux A
Mol Microbiol 1998 Jan;27(1):31-40
PubMed ID: 9466253
A novel type II secretion system in Pseudomonas aeruginosa.
Ball G, Durand E, Lazdunski A, Filloux A
Mol Microbiol 2002 Jan;43(2):475-85
PubMed ID: 11985723
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase.
Bally M, Filloux A, Akrim M, Ball G, Lazdunski A, Tommassen J
Mol Microbiol 1992 May;6(9):1121-31
PubMed ID: 1588814