Pseudomonas aeruginosa PAO1, PA2809 (copR)

Gene Feature Overview

Strain	Pseudomonas aeruginosa PAO1 (Stover et al., 2000) GCF_000006765.1|latest
Locus Tag	PA2809
Name	copR Synonym: copR
Replicon	chromosome
Genomic location	3162705 - 3163385 (+ strand)
Transposon Mutants	1 transposon mutants in PAO1
Transposon Mutants in orthologs	3 transposon mutants in orthologs
Comment	Mutation leads to hypersensitivity to copper-mediated toxicity.

Cross-References

RefSeq	NP_251499.1
GI	15598005
Affymetrix	PA2809_at
DNASU	PaCD00007219
Entrez	878672
GenBank	AAG06197.1
INSDC	AAG06197.1
NCBI Locus Tag	PA2809
protein_id(GenBank)	gb|AAG06197.1|AE004708_3|gnl|PseudoCAP|PA2809
TIGR	NTL03PA02809
UniParc	UPI00000C581B
UniProtKB Acc	Q9I034
UniProtKB ID	Q9I034_PSEAE
UniRef100	UniRef100_W0YRC7
UniRef50	UniRef50_Q58AD5
UniRef90	UniRef90_A0A024HIC4

Product

Feature Type	CDS
Coding Frame	1
Product Name	two-component response regulator, CopR Product Name Confidence: Class 1
Synonyms	two-component response regulator, CopR
Evidence for Translation	Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7)	-8.75
Kyte-Doolittle Hydrophobicity Value	-0.227
Molecular Weight (kDa)	25.7
Isoelectric Point (pI)	4.60

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543 Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001354 (1369 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA2809 Search term: copR Search term: two-component response regulator, CopR

Human Homologs

References

A two-component regulatory system required for copper-inducible expression of the copper resistance operon of Pseudomonas syringae. Mills SD, Jasalavich CA, Cooksey DA J Bacteriol 1993 Mar;175(6):1656-64 PubMed ID: 8449873