Pseudomonas aeruginosa PAO1, PA3405 (hasE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3405
Name
hasE
Replicon chromosome
Genomic location 3810610 - 3811941 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252095.1
GI 15598601
Affymetrix PA3405_hasE_at
Entrez 880019
GenBank AAG06793.1
INSDC AAG06793.1
NCBI Locus Tag PA3405
protein_id(GenBank) gb|AAG06793.1|AE004761_9|gnl|PseudoCAP|PA3405
TIGR NTL03PA03405
UniParc UPI00000C59F4
UniProtKB Acc Q9HYJ9
UniProtKB ID Q9HYJ9_PSEAE
UniRef100 UniRef100_W0YT51
UniRef50 UniRef50_W0YT51
UniRef90 UniRef90_W0YT51

Product

Feature Type CDS
Coding Frame 1
Product Name
metalloprotease secretion protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -1.76
Kyte-Doolittle Hydrophobicity Value -0.213
Molecular Weight (kDa) 48.8
Isoelectric Point (pI) 6.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 241 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001199 (788 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3405
Search term: hasE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Secretion of the Serratia marcescens HasA protein by an ABC transporter.
Létoffé S, Ghigo JM, Wandersman C
J Bacteriol 1994 Sep;176(17):5372-7
PubMed ID: 8071214