Pseudomonas aeruginosa PAO1, PA0001 (dnaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0001
Name
dnaA
Replicon chromosome
Genomic location 483 - 2027 (+ strand)

Cross-References

RefSeq NP_064721.1
GI 15595199
Affymetrix PA0001_dnaA_at
Entrez 878417
GenBank AAG03391.1
INSDC AAG03391.1
NCBI Locus Tag PA0001
protein_id(GenBank) gb|AAG03391.1|AE004440_1|gnl|PseudoCAP|PA0001
TIGR NTL03PA00002
UniParc UPI0000129539
UniProtKB Acc Q9I7C5
UniProtKB ID DNAA_PSEAE
UniRef100 UniRef100_B7V0N6
UniRef50 UniRef50_P29440
UniRef90 UniRef90_B7V0N6

Product

Feature Type CDS
Coding Frame 1
Product Name
chromosomal replication initiator protein DnaA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 6.33
Kyte-Doolittle Hydrophobicity Value -0.286
Molecular Weight (kDa) 57.7
Isoelectric Point (pI) 8.88

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold Protein Structure Database

Available for P. aeruginosa PAO1.

View predicted 3D structure in AlphaFold DB

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 584 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000001 (554 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0001
Search term: dnaA

Human Homologs

References

The nucleotide sequence of the dnaA gene and the first part of the dnaN gene of Escherichia coli K-12.
Hansen EB, Hansen FG, von Meyenburg K
Nucleic Acids Res 1982 Nov 25;10(22):7373-85
PubMed ID: 6296774
Structural analysis of the dnaA and dnaN genes of Escherichia coli.
Ohmori H, Kimura M, Nagata T, Sakakibara Y
Gene 1984 May;28(2):159-70
PubMed ID: 6234204
The E. coli dnaA initiation protein: a protein for all seasons.
Georgopoulos C
Trends Genet 1989 Oct;5(10):319-21
PubMed ID: 2558436
Pseudomonas chromosomal replication origins: a bacterial class distinct from Escherichia coli-type origins.
Yee TW, Smith DW
Proc Natl Acad Sci U S A 1990 Feb;87(4):1278-82
PubMed ID: 2106132