Pseudomonas aeruginosa UCBPP-PA14, PA14_00890 (pppA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_00890
Name
pppA
Replicon chromosome
Genomic location 87751 - 88479 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs
CommentHcp Secretion Island-I-encoded type VI secretion system (H1-T6SS)

Cross-References

RefSeq YP_788231.1
GI 116053795
Entrez 4380421
INSDC ABJ15031.1
NCBI Locus Tag PA14_00890
UniParc UPI000045D37F
UniProtKB Acc Q02V05
UniProtKB ID Q02V05_PSEAB
UniRef100 UniRef100_W0YKV9
UniRef50 UniRef50_Q9I757
UniRef90 UniRef90_Q9I757

Product

Feature Type CDS
Coding Frame 1
Product Name
PppA
Product Name Confidence: Class 1
Synonyms phosphoprotein phosphatase
Evidence for Translation
Charge (pH 7) -3.90
Kyte-Doolittle Hydrophobicity Value 0.011
Molecular Weight (kDa) 25.9
Isoelectric Point (pI) 6.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6JKV HYDROLASE 03/02/19 PppA, a key regulatory component of T6SS in Pseudomonas aeruginosa Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.6

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 392 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000074 (811 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_00890
Search term: pppA
Search term: PppA

Human Homologs

References

RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999