Pseudomonas aeruginosa PAO1, PA0336 (rppH)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest |
| Locus Tag |
PA0336
|
| Name |
rppH
Synonym: ygdP |
| Replicon | chromosome |
| Genomic location | 378096 - 378575 (+ strand) |
| Transposon Mutants | 2 transposon mutants in PAO1 |
| Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
Cross-References
| RefSeq | NP_249027.1 |
| GI | 15595533 |
| Affymetrix | PA0336_at |
| Entrez | 882290 |
| GenBank | AAG03725.1 |
| INSDC | AAG03725.1 |
| NCBI Locus Tag | PA0336 |
| protein_id(GenBank) | gb|AAG03725.1|AE004471_8|gnl|PseudoCAP|PA0336 |
| TIGR | NTL03PA00337 |
| UniParc | UPI0000130902 |
| UniProtKB Acc | Q9X4P2 |
| UniProtKB ID | RPPH_PSEAE |
| UniRef100 | UniRef100_A6UYD9 |
| UniRef50 | UniRef50_A6UYD9 |
| UniRef90 | UniRef90_A6UYD9 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
RNA pyrophosphohydrolase, RppH
|
| Synonyms |
dinucleoside oligophosphate pyrophosphatase Nudix hydrolase YgdP |
| Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
| Charge (pH 7) | 4.17 |
| Kyte-Doolittle Hydrophobicity Value | -0.500 |
| Molecular Weight (kDa) | 18.7 |
| Isoelectric Point (pI) | 9.51 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold Protein Structure Database
Available for P. aeruginosa PAO1.
| View predicted 3D structure in AlphaFold DB |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 247 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000328 (550 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA0336
Search term: rppH
Search term: RNA pyrophosphohydrolase, RppH
|
Human Homologs
References
|
The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5')-pentaphospho-(5')-adenosine (Ap5A).
Bessman MJ, Walsh JD, Dunn CA, Swaminathan J, Weldon JE, Shen J
J Biol Chem 2001 Oct 12;276(41):37834-8
PubMed ID: 11479323
|
|
Nudix-type RNA pyrophosphohydrolase provides homeostasis of virulence factor pyocyanin and functions as a global regulator in Pseudomonas aeruginosa
Kujawa M, Lirski M, Ziecina M, Drabinska J, Modzelan M, Kraszewska E.
Mol Microbiol. 2017 Nov;106(3):381-394
PubMed ID: 28833678
|