Pseudomonas aeruginosa PAO1, PA0254 (hudA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0254
Name
hudA
Synonym: ubiD
Replicon chromosome
Genomic location 284714 - 286204 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248945.1
GI 15595451
Affymetrix PA0254_at
Entrez 881878
GenBank AAG03643.1
INSDC AAG03643.1
NCBI Locus Tag PA0254
protein_id(GenBank) gb|AAG03643.1|AE004463_8|gnl|PseudoCAP|PA0254
TIGR NTL03PA00255
UniParc UPI00000C4FC3
UniProtKB Acc Q9I6N5
UniProtKB ID Q9I6N5_PSEAE
UniRef100 UniRef100_Q9I6N5
UniRef50 UniRef50_A0A022NVV4
UniRef90 UniRef90_A0A022NVV4

Product

Feature Type CDS
Coding Frame 1
Product Name
HudA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -7.29
Kyte-Doolittle Hydrophobicity Value -0.120
Molecular Weight (kDa) 54.5
Isoelectric Point (pI) 6.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4IWS LYASE 01/24/13 Putative Aromatic Acid Decarboxylase PSEUDOMONAS AERUGINOSA 2.3 X-RAY DIFFRACTION 100.0
4IP2 UNKNOWN FUNCTION 01/09/13 Putative Aromatic Acid Decarboxylase PSEUDOMONAS AERUGINOSA 1.95 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 373 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000252 (305 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0254
Search term: hudA
Search term: HudA

References

Drosophila melanogaster-based screening for multihost virulence factors of Pseudomonas aeruginosa PA14 and identification of a virulence-attenuating factor, HudA.
Kim SH, Park SY, Heo YJ, Cho YH
Infect. Immun. 2008 Sep;76(9):4152-62
PubMed ID: 18591226
Structural insights into the UbiD protein family from the crystal structure of PA0254 from Pseudomonas aeruginosa.
Jacewicz A, Izumi A, Brunner K, Schnell R, Schneider G
PLoS ONE 2013 ;8(5):e63161
PubMed ID: 23671667